Chemical Biology of Disease

CBD Handout

This handout is designed to introduce and illustrate the research happening within the LSI Research Groups.

Chemical Biology of Disease

We aim to create a multidisciplinary team of UBC scientists capable of carrying out all aspects of drug discovery. About the CBD Research Group Current Membership Recent Findings

Brayer Lab:

We are pursuing promising “hits” for novel antibiotics active against Gram–negative bacteria and mechanism-based therapeutics for diabetes and obesity.

Our studies of proteases implicated in atherosclerosis, bone and joint and autoimmune diseases have led to the identification of several promising low molecular weight inhibitors with novel binding sites.

Cullis Lab:

Our research efforts are directed towards gaining an understanding of membrane structure and function at the molecular level and using the information gained to therapeutic advantage.

Davies Lab:

The main focus is the biology of small molecules, especially antibiotics.

McIntosh Lab:

Our laboratory uses NMR spectroscopy and related biophysical methods to characterize the structure and dynamics of proteins involved in signal transduction and the regulation of gene expression and in the synthesis/degradation of carbohydrates.