Professor
Associate Member, Michael Smith Laboratories
CIHR Scientist
Department of Biochemistry and Molecular Biology
Department of Chemistry
BSc, University of Calgary (1982)
PhD, University of Oregon (1990)
Helen Hay Whitney Postdoctoral Fellow, Whitehead Institute, MIT (1991-1992)
Killam Research Prize (1998)
Alexander von Humbolt Research Fellow (1999)
Sabbatical visitor, European Molecular Biology Laboratory, Heidelberg, Germany (1999-2000)
CIHR Scientist (2000-2005)
Email: mcintosh@chem.ubc.ca
Office Tel: 604-822-3341
Lab Tel: 604-822-3029
Room 4551
Life Sciences Centre
2350 Health Sciences Mall
University of British Columbia
Vancouver, B. C. Canada V6T 1Z3
Using NMR spectroscopy, new mechnisms for the regulation of ETS transcription factors by “bead-on-a-string” sumoylation and the “rheostatic” effects of multi-site phosphorylation on DNA-binding auto-inhibition were elucidated. This may provide a new approach to the understanding and treatment of ETS-related cancers.
